Hancock Jaffe Laboratories, Inc.

70 Doppler

Irvine, California 92618


November 27, 2020




U.S. Securities and Exchange Commission

Division of Corporate Finance

100 F Street, N.E.

Mail Stop 4628

Washington, DC 20549

Attn: Alan Campbell


  Re:   Hancock Jaffe Laboratories, Inc.
      Registration Statement on Form S-1
      Filed November 6, 2020
      File No. 333-249942


Dear Mr. Campbell:


Pursuant to Rule 461 under the Securities Act of 1933, as amended, Hancock Jaffe Laboratories, Inc. hereby requests acceleration of effectiveness of the above referenced Registration Statement so that it will become effective at 4:00 p.m. EST on Monday, November 30, 2020, or as soon as thereafter practicable.


  Very truly yours,
  /s/ Robert A. Berman
  By: Robert A. Berman
  Title: Chief Executive Officer


cc:   Ellenoff Grossman & Schole LLP